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Magnesium (HVP chelate)
Magnesium is the “zen” molecule. It is a mineral essential to the body's proper functioning. Its main property is its action on the nervous system, but it has many other benefits, notably for muscles, the heart, bones and the immune system. It is particularly recommended for people suffering from stress or deficiency1. Involved in numerous metabolic reactions and the transmission of nerve signals, magnesium is essential for maintaining a regular heartbeat, lipid metabolism, as well as regulating blood sugar levels and blood pressure. Magnesium also helps prevent cardiovascular disease, migraines, diabetes, severe asthma, difficulty sleeping, premenstrual pain and pre-eclampsia2-4. Caused by a diet low in magnesium, stress, consumption of energy drinks and long-term use of certain medications (diuretics, certain antibiotics, immunosuppressants, oral contraceptives, estrogens and certain anti-cancer drugs), magnesium deficiency is difficult to diagnose3. validated by clinical trials, taking magnesium as a dietary supplement is recognized in the treatment of a number of disorders, including cardiovascular disease, migraines, diabetes, severe asthma, premenstrual syndrome and pre-eclampsia3.
Vitamin B6 (Pyridoxine HCL)
A daily intake of vitamin B6 is essential, as the body can neither produce nor accumulate this vitamin. It plays a role in the synthesis of certain antibodies and hemoglobin, and in maintaining mental equilibrium. It contributes to the proper absorption of vitamin B12 and the assimilation of magnesium by the body. According to the Society of Obstetricians and Gynaecologists of Canada (SOGC), more than half of all pregnant women suffer from nausea and vomiting. The origin of this discomfort is not clearly defined, but a serious clue, concerning vitamin B6 levels in the blood, seems to correlate with the onset and severity of the disorders3. The antiemetic effect of vitamin B6 has been known since 1942. Its effectiveness in preventing nausea during pregnancy has since been confirmed by numerous clinical trials5-9.
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Why choose Prozen?
This supplement is indicated for patients suffering from disorders associated with magnesium and vitamin B6 deficiency in men and women (nervous and/or muscular fatigue, irritability, transient tiredness, minor sleep disorders, palpitations, muscle cramps, tingling, pain associated with premenstrual syndrome, menstruation and migraines). The combination of vitamin B6 and magnesium may be more effective (than either treatment alone) against PMS symptoms.
Also indicated for pregnant women with pregnancy-related morning sickness, stress and fatigue.
How do I take my treatment?
1 capsule 3 times a day, with food a few hours before or after taking other medications.
How long should I take Prozen?
Prozen is a natural supplement that should be taken on a daily basis for an indefinite period of time. We therefore recommend that you make it part of your daily routine.
When should I stop taking Prozen?
Prozen can be taken daily for an indefinite period. However, it is important to stop taking it if your doctor recommends it.
Use of this supplement may be considered during pregnancy, if necessary. Ask your doctor or pharmacist for advice.
It is recommended not to exceed 20mg/day of vitamin B6 for breast-feeding women. Ask your doctor or pharmacist for advice.
Some people may develop diarrhea.
Contraindicated in cases of severe renal insufficiency (impaired kidney function).
- 1 Seelig, M. S. Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review). J Am Coll Nutr 13, 429-446 (1994).
- 2 De Souza, M. C., Walker, A. F., Robinson, P. A. & Bolland, K. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Womens Health Gend Based Med 9, 131-139, doi:10.1089/152460900318623 (2000).
- 3 de Baaij, J. H., Hoenderop, J. G. & Bindels, R. J. Magnesium in man: implications for health and disease. Physiol Rev 95, 1-46, doi:10.1152/physrev.00012.2014 (2015).
- 4 Guerrera, M. P., Volpe, S. L. & Mao, J. J. Therapeutic uses of magnesium. Am Fam Physician 80, 157-162 (2009).
- 5 Wibowo, N. et al. Vitamin B(6) supplementation in pregnant women with nausea and vomiting. Int J Gynaecol Obstet 116, 206-210, doi:10.1016/j.ijgo.2011.09.030 (2012).
- 6 Matok, I. et al. Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. J Clin Pharmacol 54, 1429-1433, doi:10.1002/jcph.369 (2014).
- 7 Vutyavanich, T., Wongtra-ngan, S. & Ruangsri, R. Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol 173, 881-884 (1995).
- 8 Chittumma, P., Kaewkiattikun, K. & Wiriyasiriwach, B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 90, 15-20 (2007).
- 9 Jewell, D. & Young, G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev, CD000145, doi:10.1002/14651858.CD000145 (2003).