Ubiquinol is the reduced, active form of coenzyme Q10 (CoQ10), known for its dual role as a key contributor to cellular energy production and as a powerful antioxidant¹¹. Unlike its oxidized counterpart, ubiquinone, ubiquinol is more readily absorbed by the body. This makes it especially beneficial for older adults or individuals with certain health conditions, as the natural conversion of ubiquinone to ubiquinol tends to decline with age^12,13. Due to its superior bioavailability and effectiveness, ubiquinol is often the preferred form of CoQ10 for supporting energy metabolism and overall cellular health^14,15.

Ubiquinol supplementation offers a range of health benefits, particularly in the area of reproductive health. In men, CoQ10 has been shown to enhance sperm parameters—including motility, count, morphology, and DNA integrity—ultimately supporting overall fertility⁷. In women, CoQ10 is naturally present in follicular fluid, with significantly higher concentrations found in mature oocytes compared to abnormal ones. This suggests a positive correlation between CoQ10 levels and oocyte quality^4,16. Furthermore, studies indicate that CoQ10 pretreatment may improve ovarian response and embryo quality in younger women (under 35 years) who have a poor ovarian prognosis and diminished ovarian reserve (AFC < 5, AMH < 1.2 ng/mL)¹⁷.

Beyond its role in reproductive health, ubiquinol has shown promising effects on metabolic and cardiovascular well-being.In individuals with type 2 diabetes, ubiquinol supplementation may help improve blood sugar regulation, indicating broader benefits for metabolic health¹³. Additionally, ubiquinol enhances both plasma and cellular antioxidant levels, which is essential in counteracting oxidative stress—a key contributor to many chronic diseases, including cardiovascular disorders¹⁸. These antioxidant properties make ubiquinol particularly valuable for supporting heart health, especially in aging populations and those with cardiovascular risk factors^19,20. As a potent antioxidant, ubiquinol helps protect cardiac tissue from oxidative damage, a crucial function given the heart’s high energy demand and sensitivity to oxidative stress²⁰. Lower CoQ10 levels have been observed in patients with various cardiovascular conditions such as congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse, and in those recovering from coronary revascularization¹⁰. Therefore, CoQ10 supplementation—especially in its active ubiquinol form—may offer therapeutic support for individuals affected by these conditions.