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Acetyl-l-carnitine (acetyl-l-carnitine hcl)
Acetyl-L-Carnitine is an essential amino acid and antioxidant, involved in energy production and protection against oxidative stress. There is a positive correlation between seminal L-Carnitine concentration and sperm motility, vitality and quantity. L-carnitine is also involved in sperm maturation.
Vitamin C (ascorbic acid)
Vitamin C is an antioxidant that has been shown to protect sperm DNA from oxidative damage. Clinical studies have shown that Vitamin C significantly improves sperm motility and morphology17-19.
Vitamin E (succinate)
Vitamin E is an antioxidant that maintains the viability of immature sperm and contributes to their maturation along the epididymis20,21. In addition, clinical studies have confirmed that Vitamin E improves the ability of sperm to fertilize the egg22.
Folic acid (folate, vitamin b9)
Like zinc, folic acid is directly involved in the production of spermatozoa suitable for fertilization. Folic acid is a B vitamin, necessary for the synthesis of nucleic acid (the basis of DNA) and amino acids (a source of energy)7. Its incorporation into the diet of sub-fertile men has proved its worth.
Vitamin B12 (methylcobalamin)
Vitamin B12 is an important component of seminal fluid, whose concentration is positively correlated with sperm concentration27.
Zinc (gluconate)
In addition to its role in sperm production, zinc is an important stabilizer of sperm DNA structure29. It also plays an essential role in the activity of enzymes responsible for fertilization31.
Selenium (yeast extract)
Selenium is a cofactor (component) of one of the most important antioxidant enzymes in spermatozoa. It is also a structural component of spermatozoa11,12.
VISIT OUR HEALTH RESOURCES SECTION TO LEARN MORE ABOUT THESE SPECIFIC INGREDIENTS
Why choose Fertil Pro® men + L-Carnitine?
Deficiencies in certain essential vitamins and minerals increase the risk of male infertility. Scientific and medical evidence indicates that these vitamins and minerals are essential for sperm quality. Furthermore, it is recognized that oxidative stress (linked to environmental and lifestyle factors) is primarily responsible for genetic and functional alterations in spermatozoa. Finally, numerous scientific and medical reports reveal that the essential amino acid L-carnitine is an indispensable source of energy for sperm motility7.
Daily intake of nutrients, which have been shown to help in a large number of cases of unexplained hypofertility and sperm-related problems, could increase a couple's chances of conceiving5.
These essential nutrients and minerals have been selected for formulation in Fertil Pro® men + L-Carnitine, which could improve sperm production and quality by reducing oxidative stress damage.
Taking this dietary supplement could have an impact on sperm quality and protect the integrity of the sperm's genetic information.
How do I take my treatment?
1 tablet 1 time a day. Take a few hours before taking other medications.
How long should I take Fertil Pro® men + L-Carnitine?
We recommend a course of treatment lasting a minimum of 3 months to observe profound changes and give the body time to find a new equilibrium, renewable if necessary.
It is ideal to start treatment 2 to 3 months before the start of fertility treatments.
When should I stop taking Fertil Pro® men + L-Carnitine?
Fertil Pro® men + L-Carnitine can be stopped as soon as pregnancy is confirmed.
Change in sperm
An improvement in sperm quality and quantity will be noticeable when taking Fertil Pro® men + L-Carnitine.
To optimize the benefits of Fertil Pro® men + L-Carnitine, we suggest coupling it with our Fertil Pro® MTL supplement. These two supplements are available as a combo.
A low incidence of epileptic episodes has been reported with oral doses of L-carnitine in individuals with and without a history of epileptic disorder.
Some people may experience gastrointestinal discomfort, including nausea, vomiting, abdominal cramps and diarrhea.
Zinc supplementation may cause copper deficiency.
Keep out of reach of children.
- Chawla J, Kvarnberg D. Chapter 59 - Hydrosoluble vitamins. In: Biller J, Ferro JM, editors. Handbook of Clinical Neurology. Vol. 120: Elsevier; 2014. p. 891-914.
- Butterworth CE, Jr., Tamura T. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8.
- Zini A, San Gabriel M, Baazeem A. Antioxidants and sperm DNA damage: a clinical perspective. J Assist Reprod Genet. 2009 Aug;26(8):427-32.
- Mateus FG, Moreira S, Martins AD, et al. L-Carnitine and Male Fertility: Is Supplementation Beneficial? J Clin Med. 2023 Sep 6;12(18).
- Kopets R, Kuibida I, Chernyavska I, et al. Dietary supplementation with a novel l-carnitine multi-micronutrient in idiopathic male subfertility involving oligo-, astheno-, teratozoospermia: A randomized clinical study. Andrology. 2020 Sep;8(5):1184-1193.
- Agarwal A, Said TM. Carnitines and male infertility. Reproductive BioMedicine Online. 2004 2004/01/01/;8(4):376-384.
- Nazari L, Salehpour S, Hosseini S, et al. Effect of antioxidant supplementation containing L-carnitine on semen parameters: a prospective interventional study. JBRA Assist Reprod. 2021 Feb 2;25(1):76-80.
- Lenzi A, Sgro P, Salacone P, et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertility and sterility. 2004;81(6):1578-1584.
- Fraga CG, Motchnik PA, Shigenaga MK, et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11003-6.
- Qamar AY, Naveed MI, Raza S, et al. Role of antioxidants in fertility preservation of sperm - A narrative review. Anim Biosci. 2023 Mar;36(3):385-403.
- Therond P, Auger J, Legrand A, Jouannet P. α-Tocopherol in human spermatozoa and seminal plasma: relationships with motility, antioxidant enzymes and leukocytes. MHR: Basic science of reproductive medicine. 1996;2(10):739-744.
- Wong WY, Merkus HM, Thomas CM, et al. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002 Mar;77(3):491-8.
- Li X, Zeng Y-m, He J, et al. Effects of folic acid and folic acid plus zinc supplements on the sperm characteristics and pregnancy outcomes of infertile men: A systematic review and meta-analysis. Heliyon. 2023.
- Beltrame FL, Sasso-Cerri E. Vitamin B(12)-induced spermatogenesis recovery in cimetidine-treated rats: effect on the spermatogonia number and sperm concentration. Asian J Androl. 2017 Sep-Oct;19(5):567-572.
- Banihani SA. Vitamin B(12) and Semen Quality. Biomolecules. 2017 Jun 9;7(2).
- Hosseinabadi F, Jenabi M, Ghafarizadeh AA, Yazdanikhah S. The effect of vitamin B12 supplement on post-thaw motility, viability and DNA damage of human sperm. Andrologia. 2020 Dec;52(11):e13877.
- Allouche-Fitoussi D, Breitbart H. The Role of Zinc in Male Fertility. Int J Mol Sci. 2020 Oct 21;21(20).
- Kowalczyk A. The Role of the Natural Antioxidant Mechanism in Sperm Cells. Reproductive Sciences. 2022 2022/05/01;29(5):1387-1394.
- Bermingham EN, Hesketh JE, Sinclair BR, et al. Selenium-enriched foods are more effective at increasing glutathione peroxidase (GPx) activity compared with selenomethionine: a meta-analysis. Nutrients. 2014 Sep 29;6(10):4002-31.
- 5 Skoracka K, Eder P, Łykowska-Szuber L, et al. Diet and Nutritional Factors in Male (In)fertility-Underestimated Factors. J Clin Med. 2020 May 9;9(5).
- 7 Majzoub A, Agarwal A. Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate. Arab J Urol. 2018 Mar;16(1):113-124.
- 11 Ursini F, Heim S, Kiess M, et al. Dual function of the selenoprotein PHGPx during sperm maturation. Science. 1999;285(5432):1393-1396.
- 12 Noack‐Füller G, De Beer C, Seibert H. Cadmium, lead, selenium, and zinc in semen of occupationally unexposed men. Andrologia. 1993;25(1):7-12.
- 17 Cyrus A, Kabir A, Goodarzi D, Moghimi M. The effect of adjuvant vitamin C after varicocele surgery on sperm quality and quantity in infertile men: a double blind placebo controlled clinical trial. Int Braz J Urol. 2015 Mar-Apr;41(2):230-8.
- 18 Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992 Nov;58(5):1034-9.
- 19 Henkel R, Samanta L, Agarwal A. Oxidants, antioxidants, and impact of the oxidative status in male reproduction. Academic Press; 2018.
- 20 Keskes-Ammar L, Feki-Chakroun N, Rebai T, et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl. 2003 Mar-Apr;49(2):83-94.
- 21 Suleiman SA, Ali ME, Zaki ZM, et al. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl. 1996 Sep-Oct;17(5):530-7.
- 22 Kessopoulou E, Powers HJ, Sharma KK, et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril. 1995 Oct;64(4):825-31.
- 27 Banihani SA. Vitamin B(12) and Semen Quality. Biomolecules. 2017 Jun 9;7(2).
- 31 Reichart M, Lederman H, Har-Even D, et al. Human sperm acrosin activity with relation to semen parameters and acrosomal ultrastructure. Andrologia. 1993 Mar-Apr;25(2):59-66.
- I M W Ebisch 1, F H Pierik, F H DE Jong, C M G Thomas, R P M Steegers-Theunissen. Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men? Int J Androl . 2006 Apr;29(2):339-45.
- E Geva, B Bartoov, N Zabludovsky, J B Lessing, L Lerner-Geva, A Amit. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program. Fertil Steril . 1996 Sep;66(3):430-4.
- Ermanno Greco, Stefania Romano, Marcello Iacobelli, Susanna Ferrero, Elena Baroni, Maria Giulia Minasi, Filippo Ubaldi, Laura Rienzi, Jan Tesarik. ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment. Hum Reprod . 2005 Sep;20(9):2590-4.
- Andrea Lenzi , Francesco Lombardo, Paolo Sgrò, Pietro Salacone, Luisa Caponecchia, Franco Dondero, Loredana Gandini. Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. Fertil Steril. 2003 Feb;79(2):292-300.
- Giancarlo Balercia 1, Francesco Regoli, Tatiana Armeni, Aleardo Koverech, Franco Mantero, Marco Boscaro. Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia.Fert 2005 Sep;84(3):662-71.
- Olson J. Carotenoids, Shils M, Olson J, Shike M, Ross Z. In. Modern Nutrition in Health. Baltimore, Williams & Wilkins; 1999.
- Owen KN, Dewald O. Vitamin E Toxicity. StatPearls. Treasure Island (FL): StatPearls PublishingCopyright © 2023, StatPearls Publishing LLC.; 2023.