Coenzyme Q10 (CoQ10) is a fat-soluble substance that works as a powerful antioxidant, helping to prevent lipid peroxidation and DNA oxidation in our cells¹.
Additionally, CoQ10 plays a crucial role in the body’s energy production process by assisting in the creation of ATP, which is the main energy currency of our cells¹.
CoQ10 supplements have been commonly used to improve fertility results, leading to a higher rate of successful pregnancies^2,3.
Aging is associated with a decrease in CoQ10 production^4,5.
Studies have shown that CoQ10 is present in human follicular fluid and that the concentration is notably higher in mature oocytes compared to abnormal oocytes; therefore inferring that there is a positive correlation between CoQ10 levels in follicular fluid and oocyte quality^6,7. Studies have also demonstrated that pretreatment with CoQ10 can improve ovarian response and embryo quality in young women (age < 35) with poor ovarian prognosis and decreased ovarian reserve (AFC < 5, AMH < 1.2 ng/mL)⁸.

L-arginine is a semi-essential or conditionally essential amino acid in humans^9,10. It plays a role in various biological processes including protein biosynthesis, immune response, and the production of nitric oxide, which is a vasodilator^9,10.
L-arginine improves follicular and endometrial blood flow which may enhance embryo implantation^11,12.
In addition, L-arginine supplementation has been shown to improve endometrial thickness in patients with a thin endometrium (< 8 mm)⁹.
In poor responder patients undergoing in-vitro fertilization, L-arginine supplementation may improve ovarian response, endometrial receptivity, and pregnancy rate, which could be beneficial for women with PCOS undergoing fertility treatments¹¹.

Resveratrol is a natural polyphenolic compound found in plants and fruits¹³. It is known for its antioxidant, anti-inflammatory, and anti-proliferative properties¹³.
Resveratrol enhances mitochondrial function and biogenesis in granulosa cell cultures, leading to improved outcomes in folliculogenesis during intracytoplasmic sperm injection (ICSI) treatments^14,15.
Resveratrol has shown promise in reducing endometriosis symptoms and lesion size through its anti-inflammatory and anti-angiogenic properties, as evidenced by significant pain relief in patients, reduced dysmenorrhea, and reduced endometrial implant volumes in experimental models^16-18.
Additionally, it was observed that resveratrol supplementation could potentially ameliorate symptoms associated with polycystic ovary syndrome (PCOS)¹⁹. This includes reducing insulin resistance and enhancing ovarian morphology^19,20.
Resveratrol also appears to regulate reproductive hormones and decrease inflammation and oxidative stress by impacting relevant biological pathways^19,21.