SIGN UP AND SAVE 5%


Why Choose Floria
The presence of a Lactobacillus-dominated vaginal microbiota is particularly crucial for female reproductive health, as it provides protection against various fertility-related issues3. This protective role is attributed to the ability of Lactobacillus strains to modulate both the vaginal microbiota and inflammatory cytokines, thereby promoting an environment favorable to pregnancy1. This role is especially evident in the case of bacterial vaginosis, which is associated with an increased risk of miscarriage and preterm birth4. The use of probiotics for the prevention or treatment of bacterial vaginosis is based on their ability to restore vaginal microbiota balance, which may improve the intrauterine environment and fertility outcomes5. Additionally, several studies have shown that patients with polycystic ovary syndrome (PCOS) often exhibit a significant reduction in beneficial bacteria, which are involved in immune support and nutrient absorption6. Probiotics have therefore shown promise in improving hormonal and inflammatory profiles in these patients7. These findings suggest that probiotics may have a broader role in fertility beyond maintaining vaginal health, also influencing systemic hormonal and inflammatory pathways.
How do I take my treatment
Use 1 vaginal suppository per day.
If you are using other vaginal products, it is advisable to allow a few hours between applications before using Floria.
How long should I take Floria:
We recommend using Floria for at least 14 days to establish a stable microbiota. For optimal results, start with two consecutive 14-day courses.
The treatment can be paused during menstruation and resumed afterward and may be repeated if necessary.
When Floria should be stopped:
There is no time limit for taking Floria, which supports the optimal balance of the vaginal flora.
However, it is recommended to start with two consecutive 14-day courses, and then continue as needed, based on your doctor’s advice.
There are no contraindications for use during pregnancy.
Consult a healthcare professional before use in case of nausea, vomiting, or severe pain.
Discontinue use and consult a doctor if symptoms such as diarrhea worsen or persist for more than three days. Seek medical advice if you are pregnant.
Keep out of reach of children.
Do not use this product if you have an immunodeficiency (e.g., AIDS, lymphoma, or if you are on long-term corticosteroid treatment).
- Mei Z, Li D. The role of probiotics in vaginal health. Front Cell Infect Microbiol. 2022;12:963868.
- Amabebe E, Anumba DOC. The Vaginal Microenvironment: The Physiologic Role of Lactobacilli. Front Med (Lausanne). 2018;5:181.
- Zhang F, Dai J, Chen T. Role of Lactobacillus in Female Infertility Via Modulating Sperm Agglutination and Immobilization [Review]. Frontiers in Cellular and Infection Microbiology. 2021 2021-January-25;10.
- Liu P, Lu Y, Li R, Chen X. Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations. Front Cell Infect Microbiol. 2023;13:1153894.
- Basavaprabhu HN, Sonu KS, Prabha R. Mechanistic insights into the action of probiotics against bacterial vaginosis and its mediated preterm birth: An overview. Microb Pathog. 2020 Apr;141:104029.
- Giampaolino P, Foreste V, Di Filippo C, et al. Microbiome and PCOS: State-of-Art and Future Aspects. Int J Mol Sci. 2021 Feb 19;22(4).
- Di Lorenzo M, Cacciapuoti N, Lonardo MS, et al. Pathophysiology and Nutritional Approaches in Polycystic Ovary Syndrome (PCOS): A Comprehensive Review. Curr Nutr Rep. 2023 Sep;12(3):527-544.
- Reid G, Bruce AW, Fraser N, et al. Oral probiotics can resolve urogenital infections. FEMS Immunology & Medical Microbiology. 2001;30(1):49-52.
- Rapisarda AMC, Pino A, Grimaldi RL, et al. Lacticaseibacillus rhamnosus CA15 (DSM 33960) strain as a new driver in restoring the normal vaginal microbiota: A randomized, double-blind, placebo-controlled clinical trial. Front Surg. 2022;9:1075612.
- Pino A, Rapisarda AMC, Vitale SG, et al. A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis. Scientific Reports. 2021 2021/01/28;11(1):2592.
- Petrova MI, Lievens E, Verhoeven TLA, et al. The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens. Scientific Reports. 2016 2016/11/21;6(1):37437.
- Recine N, Palma E, Domenici L, et al. Restoring vaginal microbiota: biological control of bacterial vaginosis. A prospective case-control study using Lactobacillus rhamnosus BMX 54 as adjuvant treatment against bacterial vaginosis. Arch Gynecol Obstet. 2016 Jan;293(1):101-107.
- Tachedjian G, Aldunate M, Bradshaw CS, Cone RA. The role of lactic acid production by probiotic Lactobacillus species in vaginal health. Research in Microbiology. 2017 2017/11/01/;168(9):782-792.
- Wu S, Hugerth LW, Schuppe-Koistinen I, Du J. The right bug in the right place: opportunities for bacterial vaginosis treatment. npj Biofilms and Microbiomes. 2022 2022/05/02;8(1):34.
- Schwecht I, Nazli A, Gill B, Kaushic C. Lactic acid enhances vaginal epithelial barrier integrity and ameliorates inflammatory effects of dysbiotic short chain fatty acids and HIV-1. Scientific Reports. 2023 2023/11/16;13(1):20065.
- Amato V, Papaleo E, Pasciuta R, et al. Differential Composition of Vaginal Microbiome, but Not of Seminal Microbiome, Is Associated With Successful Intrauterine Insemination in Couples With Idiopathic Infertility: A Prospective Observational Study. Open Forum Infectious Diseases. 2019;7(1).
- Strus M, Chmielarczyk A, Kochan P, et al. Studies on the effects of probiotic Lactobacillus mixture given orally on vaginal and rectal colonization and on parameters of vaginal health in women with intermediate vaginal flora. Eur J Obstet Gynecol Reprod Biol. 2012 Aug;163(2):210-5.
- Zeng Z, Zuo F, Marcotte H. Putative Adhesion Factors in Vaginal Lactobacillus gasseri DSM 14869: Functional Characterization. Applied and Environmental Microbiology. 2019;85(19):e00800-19.
- Lledo B, Fuentes A, Lozano FM, et al. Identification of vaginal microbiome associated with IVF pregnancy. Scientific Reports. 2022 2022/04/26;12(1):6807.