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Inositol (MYO-DCI 40/1)
Inositol is a metabolite naturally present in the ovaries, which is deficient in women with PCOS. Clinically validated by numerous studies, inositol is known to treat PCOS symptoms through its insulin-sensitizing properties2,3. Restoring inositol levels through dietary supplements helps reduce the consequences of insulin resistance, such as the metabolic disorders associated with PCOS, including hirsutism, ovulation defects and menstrual cycle irregularity2. Furthermore, in assisted reproduction (ART), inositol is known to improve ovarian response to fertility treatments, as well as egg and embryo quality, while reducing the risk of ovarian hyperstimulation2-5.
N-acetyl-L-cysteine (NAC)
NAC is an antioxidant amino acid with an insulin-sensitizing effect. At equivalent doses, it is as effective as metformin in regulating the menstrual cycle and reducing fasting insulin levels, weight, free testosterone and hirsutism6. In PMA, NAC is clinically recognized for protecting eggs from oxidative stress, improving their quality and increasing fertilization rates7.
Chromium (chromium (III) picolinate) and vanadium (vanadium chelate product PVH)
Chromium and vanadium8 are very important trace elements in glucose metabolism. They help maintain healthy blood sugar levels9,10. Chromium has also been shown to reduce triglyceride and bad cholesterol levels in the bloodstream, while helping to raise good cholesterol levels11-14. Last but not least, scientific reports also describe chromium as a moderator of the appetite for sweet foods10. Chromium thus helps prevent the onset of metabolic syndrome and contributes to healthy weight control.
VISIT OUR HEALTH RESOURCES SECTION TO LEARN MORE ABOUT THESE SPECIFIC INGREDIENTS
Why choose Inosia?
Inosia is a unique combination of products designed to reduce the symptoms of PCOS.
PCOS is the most common endocrine disorder in women. It affects between 6% and 18% of women of reproductive age1. In addition to the characteristic ovulatory dysfunctions, PCOS is most often accompanied by hirsutism, metabolic disorders (insulin resistance, type-2 diabetes, overweight, hypertension and hyperlipidemia), chronic inflammation, and menstrual irregularity2.
How do I take my treatment?
Take 2 capsules 2 times a day with food.
How long should I take Inosia?
We recommend a course of treatment lasting 3 to 6 months, renewable if necessary.
We encourage our patients to take a course of treatment lasting at least 3 months, in order to observe profound changes and give the body time to find a new equilibrium.
It is ideal to start treatment 3 to 6 months before fertility treatments.
When to stop taking Inosia
Inosia should be stopped as soon as pregnancy is confirmed.
Consult a health care practitioner before using this product if you suffer from liver disorders, or if symptoms of liver disorders develop, if you suffer from diabetes, if you are taking hormone-based medications such as progesterone preparations, oral contraceptives or hormone replacement therapy, or if certain symptoms persist or worsen.
- 1 March, W. A. et al. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod 25, 544-551, doi:10.1093/humrep/dep399 (2010).
- 2 Garg, D. & Tal, R. Inositol Treatment and ART Outcomes in Women with PCOS. Int J Endocrinol 2016, 1979654, doi:10.1155/2016/1979654 (2016).
- 3 Dinicola, S., Chiu, T. T., Unfer, V., Carlomagno, G. & Bizzarri, M. The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome. J Clin Pharmacol 54, 1079-1092, doi:10.1002/jcph.362 (2014).
- 4 Bevilacqua, A. et al. Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology--assisted reproduction technology. Gynecol Endocrinol 31, 441-446, doi:10.3109/09513590.2015.1006616 (2015).
- 5 Facchinetti, F. et al. Results from the International Consensus Conference on Myo-inositol and d-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS. Eur J Obstet Gynecol Reprod Biol 195, 72-76, doi:10.1016/j.ejogrb.2015.09.024 (2015).
- 6 Fulghesu, A. M. et al. N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril 77, 1128-1135 (2002).
- 7 Cheraghi, E., Mehranjani, M. S., Shariatzadeh, M. A., Esfahani, M. H. & Ebrahimi, Z. N-Acetylcysteine improves oocyte and embryo quality in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection: an alternative to metformin. Reprod Fertil Dev 28, 723-731, doi:10.1071/RD14182 (2016).
- 8 Goldfine, A. B. et al. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism 49, 400-410 (2000).
- 9 Cicero, A. F., Tartagni, E. & Ertek, S. Nutraceuticals for metabolic syndrome management: from laboratory to benchside. Curr Vasc Pharmacol 12, 565-571 (2014).
- 10 Anton, S. D. et al. Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther 10, 405-412, doi:10.1089/dia.2007.0292 (2008).
- 11 Lee, N. A. & Reasner, C. A. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care 17, 1449-1452 (1994).
- 12 Roeback, J. R., Jr., Hla, K. M., Chambless, L. E. & Fletcher, R. H. Effects of chromium supplementation on serum high-density lipoprotein cholesterol levels in men taking beta-blockers. A randomized, controlled trial. Ann Intern Med 115, 917-924 (1991).
- 13 Anderson, R. A. et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 46, 1786-1791 (1997).
- 14 Anderson, R. A. Chromium in the prevention and control of diabetes. Diabetes Metab 26, 22-27 (2000).