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Vitamin A (acetate)
The benefits of vitamin A are well recognized in the preconception period and during pregnancy. Vitamin A supports implantation, embryonic development and placenta formation. More specifically, it is involved in eye formation and prevents malformations, low birth weight and maternal anemia2. That's why it's essential to ensure a sufficient intake of vitamin A for the health of both mother and child.
B vitamins: B6, B12, B9 (folic acid)
In the context of pregnancy planning, folate supplementation is essential. Folic acid, or vitamin B9, combined with prenatal vitamins such as B6 and B12, reduces the risk of congenital diseases, including neurological abnormalities, as early as the preconception period. Vitamin B6 and B12 levels naturally decrease during pregnancy4. However, the absence of a rich nutritional intake of vitamins B6 and B12 increases the risk of anemia and pre-eclampsia in the mother, and increases the risk of skeletal and neuromotor abnormalities in the child. Their intake should be encouraged in women who are vegetarians or who eat little animal products (meat, fish, eggs, dairy products). It should also be noted that there is a positive correlation between blood levels of vitamin B6 and B12 during pregnancy and the vitamin B content of breast milk during the first 6 months after birth.
Vitamin D3
Vitamin D deficiency is frequently observed in pregnant women between early autumn and late winter5. Vitamin D3 is known to support bone growth and maintain a balanced immune system. Clinically observed, women deficient in vitamin D during pregnancy are more likely to develop gestational diabetes, pre-eclampsia or bacterial vaginosis, and are more likely to give birth to a low-weight child6. This is why vitamin D supplementation is indicated during pregnancy.
Vitamin E (tocopherol)
Vitamin E is essential for reproductive functions7. It is involved in the development of the bloodstream that nourishes the fetus and participates in the formation of the brain and many other organs of the future baby8. Medical reports indicate that vitamin E deficiency during pregnancy can lead to miscarriage, pre-term delivery, pre-eclampsia and intra-uterine growth restriction9-11. It is therefore essential to include vitamin E in the diet of expectant mothers, both during the preconception period and throughout pregnancy.
Minerals: iron, zinc, copper, iodine
Mineral requirements are increased during pregnancy. Vitamin B6 improves iron absorption, thus preventing maternal anemia and its consequences for the fetus. Pregnant women need more iron due to increased blood volume and the fact that during the third trimester of pregnancy, the fetus stores the iron reserves it will need for the first six months of life. This will have an effect on the normal development of the infant's brain. Zinc, copper and iron share the same role on the infant's brain, and thanks to their antioxidant properties, zinc and copper stimulate the immune system12. Finally, iodine is essential for thyroid function. The thyroid produces maternal hormones, which are involved in brain development during the prenatal period. Iodine deficiency can adversely affect the neurological development of the fetus13.
Fatty acids: DHA (300 mg), EPA (70 mg)
Levels of essential fatty acids such as DHA and EPA decrease during pregnancy, and their deficiency may impair optimal fetal development14. Adequate nutritional intake promotes uterine growth and may reduce the risk of premature delivery, improve fetal brain and cognitive function, and protect both baby and mother from heart disease15.
VISIT OUR HEALTH RESOURCES SECTION TO LEARN MORE ABOUT THESE SPECIFIC INGREDIENTS
Why choose Progestia®?
Clinically recognized, multiple micronutrient deficiencies in the population can impair fertility, embryonic development and infant health, and increase the risk of pregnancy complications such as pre-eclampsia and gestational diabetes1. As a result, adequate nutritional status is an essential prerequisite for optimal development during intra-uterine life, the positive repercussions of which will influence the health of both mother and future infant.
This multivitamin formula, enriched with minerals and fatty acids, promotes a healthy immune balance and protects against oxidative stress, as well as the undesirable effects of deficiencies during pregnancy.
How do I take my treatment?
1 capsule per day, preferably in the evening. Swallow with a large glass of water.
How long should I take Progestia®?
For the entire duration of your pregnancy.
As Progestia® is an excellent supplement to support health in general, it is also possible to continue treatment after childbirth.
When to stop taking Progestia®
You can stop Progestia® after giving birth or continue the treatment for its general health benefits.
Some people may experience constipation, gastrointestinal discomfort, nausea, diarrhea and/or vomiting.
Goh, Y. I., Bollano, E., Einarson, T. R. & Koren, G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can 28, 680-689 (2006). - 1 Bailey RL, West KP, Jr., & Black RE (2015) The epidemiology of global micronutrient deficiencies. Ann NutrMetab 66 Suppl 2:22-33.
- 2 Clagett-Dame, M. & Knutson, D. Vitamin A in reproduction and development. Nutrients 3, 385-428, doi:10.3390/nu3040385 (2011).
- 4 Dror, D. K. & Allen, L. H. Interventions with vitamins B6, B12 and C in pregnancy. Paediatr Perinat Epidemiol 26 Suppl 1, 55-74, doi:10.1111/j.1365-3016.2012.01277.x (2012).
- 5 Rodriguez-Dehli, A. C. et al. [Prevalence of vitamin d deficiency and insuffiency and associated factors in pregnant women of northern Spain]. Nutr Hosp 31, 1633-1640, doi:10.3305/nh.2015.31.4.8448 (2015).
- 6 Aghajafari, F. et al. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ 346, f1169, doi:10.1136/bmj.f1169 (2013).
- 7 Gagne, A., Wei, S. Q., Fraser, W. D. & Julien, P. Absorption, transport, and bioavailability of vitamin e and its role in pregnant women. J Obstet Gynaecol Can 31, 210-217 (2009).
- 8 Zingg, J. M., Meydani, M. & Azzi, A. alpha-Tocopheryl phosphate--an activated form of vitamin E important for angiogenesis and vasculogenesis? Biofactors 38, 24-33, doi:10.1002/biof.198 (2012).
- 9 Rumbold, A. R. et al. Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med 354, 1796-1806, doi:10.1056/NEJMoa054186 (2006).
- 10 Yanik, F. F., Amanvermez, R., Yanik, A., Celik, C. & Kokcu, A. Pre-eclampsia associated with increased lipid peroxidation and decreased serum vitamin E levels. Int J Gynaecol Obstet 64, 27-33 (1999).
- 11 Traber, M. G. Vitamin E inadequacy in humans: causes and consequences. Adv Nutr 5, 503-514 (2014).
- 12 Hovdenak, N. & Haram, K. Influence of mineral and vitamin supplements on pregnancy outcome. Eur J Obstet Gynecol Reprod Biol 164, 127-132, doi:10.1016/j.ejogrb.2012.06.020 (2012).
- 13 Granfors, M. et al. Iodine deficiency in a study population of pregnant women in Sweden. Acta Obstet Gynecol Scand, doi:10.1111/aogs.12713 (2015).
- 14 Markhus, M. W. et al. Docosahexaenoic Acid Status in Pregnancy Determines the Maternal Docosahexaenoic Acid Status 3-, 6- and 12 Months Postpartum. Results from a Longitudinal Observational Study. PLoS One 10, e0136409, doi:10.1371/journal.pone.0136409 (2015).
- 15 Bobinski, R. & Mikulska, M. The ins and outs of maternal-fetal fatty acid metabolism. Acta Biochim Pol, doi:10.18388/abp.2015_1067 (2015).